Positron emission tomography and magnetic resonance imaging of the brain in experimental human malaria, a prospective cohort study

J Woodford; A Gillman; P Jenvey; J Roberts; S Woolley; BE Barber; M Fernandez; S Rose; P Thomas; NM Anstey; JS McCarthy

Journal article

Positron emission tomography and magnetic resonance imaging of the brain in experimental human malaria, a prospective cohort study

J Woodford, A Gillman, P Jenvey, J Roberts, S Woolley, BE Barber, M Fernandez, S Rose, P Thomas, NM Anstey, JS McCarthy

Scientific Reports | NATURE PORTFOLIO | Published : 2022

DOI: 10.1038/s41598-022-09748-y

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Abstract

Cerebral malaria is the most serious manifestation of severe falciparum malaria. Sequestration of infected red blood cells and microvascular dysfunction are key contributing processes. Whether these processes occur in early stage disease prior to clinical manifestations is unknown. To help localize and understand these processes during the early stages of infection, we performed 18-F fluorodeoxyglucose positron emission tomography/magnetic resonance imaging in volunteers with Plasmodium falciparum induced blood stage malaria (IBSM) infection, and compared results to individuals with P. vivax infection, in whom coma is rare. Seven healthy, malaria-naïve participants underwent imaging at basel..

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University of Melbourne Researchers

James McCarthy Author

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Grants

Awarded by Global Health Innovative Technology Fund

Funding Acknowledgements

This project was supported by a HIRF Seed Funding Grant, Metro North Hospital and Health Service (J.W) and by the Australian National Health and Medical Research Council (J.S.M #1,135,955, #1,037,304, #1,132,975, and N.M.A #1,135,820, 1,098,334). The clinical trials contributing participants were funded by the Australian National Health and Medical Research Council (J.S.M #1,132,975), the Bill and Melinda Gates Foundation (J.S.M OPP1111147) and the Global Health Innovative Technology Fund. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.